Adjuvant Endocrine Therapy for Premenopausal Women With Early Breast Cancer
نویسندگان
چکیده
From the Division of Medical Oncology, Department of Medicine, European Institute of Oncology, Milan, Italy; International Breast Cancer Study Group Coordinating Center, Bern; Oncology Institute of Southern Switzerland, Bellinzona & Lugano, Switzerland; International Breast Cancer Study Group Statistical Center, Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute; and Frontier Science and Technology Research Foundation, Boston, MA.
منابع مشابه
Role of Ovarian Function Suppression in Premenopausal Women with Early Breast Cancer
Historically, endocrine therapy for breast cancer began with ovarian ablation (OA) for the treatment of premenopausal patients. After the identification of estrogen receptors and the development of many antiestrogens, tamoxifen has been approved and used as the standard endocrine therapy for hormonal receptor (HR)-positive premenopausal patients to date. With the development of luteinizing horm...
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Adjuvant endocrine therapy is an integral component of care for endocrine-dependent breast cancer. The aim of this type of therapy is to counteract the production and the action of estrogens. The ovary is the primary site of estrogen production in premenopausal women, whereas, in postmenopausal women, the main source of estrogens is adipose tissue. Therefore, ovarian function suppression is an ...
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The optimal endocrine therapy for premenopausal women with early and advanced breast cancer still remains an important and controversial issue. For over 30 years, tamoxifen has been the gold standard in the adjuvant setting. New therapeutic options, such as the addition of ovarian function suppression to oral endocrine therapy (either tamoxifen or aromatase inhibitors), can improve outcomes ove...
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43 Vol. 10 No. 1, January-March 2008 Introduction Breast cancer is the most common cancer diagnosed in women in North America and 25 % of them are premenopausal (1). The young pre-menopausal and perimenopausal women constitute a significant group of patients with breast cancer and their specific treatment requires careful consideration. Approximately 60% of tumors in pre-menopausal women are ho...
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تاریخ انتشار 2005